British Medical Journal

29% more patients improved under chiropractic care than those treated medically. This was measured during the three years after treatment, comparing pain, daily activities of living and satisfaction with their treatment. Chiropractic patients also expressed better sleep and were able to sit for longer periods.

How safe is medicine?

Journal of the American Medical Association 1998 106,000 Americans die each year from drugs prescribed by their MD Journal of the American Medical Association 1998 Over 2 million Americans become seriously ill each year from reactions to medications prescribed to them by their MD Gerlin Reader’s Digest 120,000 iatrogenic deaths annually each year in the US. 1 in 200 patients die from hospital mistakes New England Journal of Medicine 1999 16,500 deaths each year from NSAIDs Journal of Rheumatology 1992 1 in 2,500 osteoarthritis patients die each year related to NSAID use NCMIC 2001 The risk of tetraplegia or death resulting from NSAID use is 160-1,500 times greater than the risk due to manipulation US Department of Labor and Statistics 2 in 100 mortality rate from spinal fusion surgery

How safe is chiropractic?

Journal of the Canadian Chiropractic Association 1 in 3,846,153 neck manipulations Journal of Manipulative and Physiological Therapeutics 1995 1 in 2,000,000 neck manipulations Journal of Manipulative and Physiological Therapeutics 1996 1 in 900,000 upper cervical manipulations Canadian Medical Association Journal 2001 1 in 5,850,000 neck manipulations Canadian Chiropractic Protective Association No claims against chiropractors for death or stroke NCMIC 2001 (Chiropractic malpractice insurance carrier) Only 19 deaths worldwide for a 65 year period, from 1934-1999

Most significant fact

Safety comparison Activity Risk of death per person, per year soccer and football one in 25,000 taking contraceptives one in 5,000 motorcycling one in 50 skiing one in 430,000 drinking one bottle of wine per day one in 13,300 driving one in 5,900 smoking two packs of cigarettes per day one in 200 professional boxing one in 14,300 taking NSAIDs one in 2,500 hospital stay one in 200

chiropractic manipulation one in 6,842,106

Sources as cited and www.centrechiro.com

Bonnie J. Kaplan, Ph.D.,1,2 Susan G. Crawford, M.Sc.,2 Beryl Gardner, M.D.,2,3 and Geraldine Farrelly, M.D.1,2 ABSTRACT A micronutrient supplement containing a broad range of dietary minerals and vitamins is being examined for the treatment of mood lability in both adults and children (Kaplan et al. 2001; Popper 2001). During pilot work, two medication-free boys with mood lability and explosive rage were studied in an open-label treatment followed by reversal and retreatment. One child was an 8-year-old with atypical obsessive-compulsive disorder, and the other was a 12-year-old with pervasive developmental delay. Both boys were monitored using the mood and temper items from the Conners Parent Rating Scale, as well as the Child Behavior Checklist. In addition, the boy with atypical obsessive-compulsive disorder was monitored with the child version of the Yale-Brown Obsessive Compulsive Scale. Both boys benefited from the micronutrient supplement when examined in ABAB designs: mood, angry outbursts, and obsessional symptoms improved when initially treated, returned when not taking the supplement,and remitted when the micronutrient supplement was reintroduced. Both boys have been followed and are stable on the nutritional supplement for over 2 years. These cases suggest that mood lability and explosive rage can, in some cases, be managed with a mixture of biologically active minerals and vitamins, without using lithium or other traditional psychopharmacologic agents. 205 JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY Volume 12, Number 3, 2002 © Mary Ann Liebert, Inc. Pp. 205–219 1Department of Paediatrics, University of Calgary, 2Alberta Children’s Hospital, 3Alberta Mental Health Services, Calgary, Alberta, Canada. Some of these results were presented at the April 2001 annual meeting of the Society for Pediatric Research.

INTRODUCTION OVER 70 YEARS AGO, researchers identified irritability and mood problems as being associated with vitamin deficiencies (Hoobler 1928), and clinicians reported positive results of treating mental illness with various essential trace minerals (English 1929; Reed 1929). Lithium is of course the most salient example of a mineral that affects mood disorders, but there are other findings that have been relatively neglected over the years. A literature has gradually accumulated that supports the notion that specific dietary nutrients, especially essential minerals, influence mood and mood disorders (Werbach 1999).

Calcium imbalances have been found to influence mood. Hyperparathyroidism is associated with changes in anxiety, depression, and cognitive function (Linder et al. 1988; Okamoto et al. 1997), and abnormally low intracellular calcium levels have been documented in patients with bipolar disorder (Dubovsky et al. 1992, 1994). Zinc, as another example, is known to play an important role in brain function and mammalian brain development (Sandstead 1985; Sandstead et al. 2000),

and relative zinc deficiency may also play a role in the expression of certain psychiatric conditions. Serum zinc levels were significantly lower in 48 adults with unipolar depression compared to 32 normal volunteers, and the severity of zinc deficiency correlated with the severity of the depressive symptoms (Maes et al. 1994, 1997). In another study, serum zinc levels were found to be lower in 43 children with attention deficit hyperactivity disorder (ADHD) than in controls (Toren et al. 1996). Lower zinc levels correlated with severity of aggressive behavior in 135 assaultive incarcerated males compared to controls (Walsh et al. 1997).

Similarly, serious iron deficiency, though rare in North America, is associated with irritability and aggression (Benton and Donohoe 1999).

Some additional examples are selenium (Benton and Cook 1990) and chromium (McLeod et al. 1999). Werbach MR: Nutritional influences on mental illness: A Sourcebook of Clinical Research, 2nd ed. Tarzana (California), Third Line Press, 1999. Address reprint requests to: Bonnie J. Kaplan, Ph.D. Alberta Children’s Hospital 1820 Richmond Road, SW Calgary, AB T2T 5C7 Canada E-mail: kaplan@ucalgary.ca TREATMENT OF MOOD WITH NUTRIENTS 219

ABSTRACT {American Journal of Clinical Nutrition} As many as one-third of mutations in a gene result in the corresponding enzyme having an increased Michaelis constant, or Km, (decreased binding affinity) for a coenzyme, resulting in a lower rate of reaction. About 50 human genetic diseases due to defective enzymes can be remedied or ameliorated by the administration of high doses of the vitamin component of the corresponding coenzyme, which at least partially restores enzymatic activity. Several single-nucleotide polymorphisms, in which the variant amino acid reduces coenzyme binding and thus enzymatic activity, are likely to be remediable by raising cellular concentrations of the cofactor through high-dose vitamin therapy.

Some examples include the alanine-to-valine substitution at codon 222 (Ala222→Val) [DNA: C-to-T substitution at nucleotide 677 (677C→T)] in methylenetetrahydrofolate reductase (NADPH) and the cofactor FAD (in relation to cardiovascular disease, migraines, and rages), the Pro187→Ser (DNA: 609C→T) mutation in NAD(P):quinone oxidoreductase 1 [NAD(P)H dehydrogenase (quinone)] and FAD (in relation to cancer), the Ala44→Gly (DNA: 131C→G) mutation in glucose-6-phosphate 1-dehydrogenase and NADP (in relation to favism and hemolytic anemia), and the Glu487→Lys mutation (present in one-half of Asians) in aldehyde dehydrogenase (NAD+) and NAD (in relation to alcohol intolerance, Alzheimer disease, and cancer). Am J Clin Nutr 2002;75:616–58. KEY WORDS Genetic disease, therapeutic vitamin use, binding defect, favism, alcohol intolerance, autism, migraine headaches, single nucleotide polymorphisms, enzyme mutations, review INTRODUCTION High doses of vitamins are used to treat many inheritable human diseases. The molecular basis of disease arising from as many as one-third of the mutations in a gene is an increased Michaelis constant, or Km, (decreased binding affinity) of an enzyme for the vitamin-derived coenzyme or substrate, which in turn lowers the rate of the reaction. The Km is a measure of the binding affinity of an enzyme for its ligand (substrate or coenzyme) and is defined as the concentration of ligand required to fill one-half of the ligand binding sites.

It is likely that therapeutic vitamin regimens increase intracellular ligand (cofactor) concentrations, thus activating a defective enzyme; this alleviates the primary defect and remediates the disease. We show in this review that _50 human genetic diseases involving defective enzymes can be remedied by high concentrations of the vitamin component of the coenzyme, and that this therapeutic technique can be applied in several other cases, including polymorphisms associated with disease risks, for which molecular evidence suggests that a mutation affects a coenzyme binding site.


The nutrients discussed in this review are pyridoxine (B-6) (page 618); thiamine (page 625); riboflavin (page 627); niacin (page 632); biotin ( (B1)page 637); cobalamin (B12) (page 638); folic acid (page 641); vitamin K (page 643); calciferol (D) (page 645); tocopherol (E) (page 645); tetrahydrobiopterin (dervived from Folate)(page 646); S-adenosylmethionine (SAM-e) (page 646); pantothenic acid(B5)(page 646); lipoic acid (page 647); carnitine (page 647); hormones, amino acids, and metals (page 648); and maxi B vitamins (page 649)

The proportion of mutations in a disease gene that is responsive to high concentrations of a vitamin or substrate may be one-third or greater (1–3). Determining the true percentage from the literature is difficult because exact response rates in patients are not always reported and much of the literature deals only with individual case reports. The true percentages depend on several factors, such as the nature of the enzyme, the degree of enzyme loss that results in a particular phenotype, how much a small conformational change disrupts the binding site of the particular enzyme, whether the binding site is a hot spot for mutations, and whether dietary administration of the biochemical raises its concentration in the cell.

From what is known of enzyme structure, it seems plausible that, in addition to direct changes in the amino acids at the coenzyme binding site, some mutations affect the conformation of the protein, thus causing an indirect change in the binding site.

Am J Clin Nutr 2002;75:616–58. Printed in USA. © 2002 American Society for Clinical Nutrition High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): relevance to genetic disease and polymorphisms1–3 Bruce N Ames, Ilan Elson-Schwab, and Eli A Silver 616 1 From the Department of Molecular and Cellular Biology, University of California, Berkeley (BNA, IE-S, and EAS), and the Children’s Hospital Oakland Research Institute, Oakland, CA (BNA and IE-S). 2 Supported by grants to BNA from the Ellison Foundation (SS0422-99), the National Foundation for Cancer Research (M2661), the Wheeler Fund of the Dean of Biology, and the National Institute of Environmental Health Sciences Center (ES01896). 3 Address reprint requests to BN Ames, Children’s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609. E-mail: bames@chori.org. Received September 20, 2001. Accepted for publication December 19, 2001.

Acetaminophen Found in more than 100 OTC preparations, including Sudafed®, Theraflu®, and Tylenol®, acetaminophen is used to reduce pain and fever. It has been available in the United States since 1960. Unlike NSAIDs, acetaminophen does not reduce inflammation or blood clotting or cause gastric complications (Roberts LJ et al 2001).

Nevertheless, acetaminophen overdose is one the most common causes of OTC drug poisoning in the United States and Britain. More than 30,000 cases per year of acetaminophen overdose are reported to the American Association of Poison Control Centers (Bartlett D 2004).

It is a leading cause of liver failure in the Western world and the leading cause of drug-induced liver failure in the United States (Bartlett D 2004).

People who have liver disorders or who consume large amounts of alcohol are advised to avoid acetaminophen, which can damage both the kidneys and the liver, even at therapeutic doses (Bromer MQ et al 2003).

People who use acetaminophen on a regular basis double their risk of kidney cancer (Kaye JA et al 2001; Gago-Dominguez M et al 1999; Derby LE et al 1996).

Toxicity Acetaminophen is extremely toxic to adults in single large doses of about 7000 mg (or 150 mg per kilogram of body weight). This large amount in one setting, however, is relatively rare. Instead, most cases of acetaminophen poisoning occur because people take smaller doses over a long period of time.

In this setting, doses of 4000 mg daily can be toxic. In children, daily maximum oral dosing is not to exceed 90 mg per kilogram of body weight (O’Malley P 2005).

Acetaminophen poisoning affects the liver similarly to any other toxin, including alcohol. At higher doses, the drug can no longer be metabolized by the liver, and the excess is oxidized into a toxic metabolite. This causes a rapid depletion of the internal antioxidants glutathione and S-adenosyl-L-methionine in the liver. When glutathione levels are reduced too far, liver cell death begins to occur.

Symptoms of Overdose Within 24 hours of a toxic dose of acetaminophen), nausea, vomiting, and abdominal tenderness may be present. Elevation of liver enzymes can occur from an acute dose as soon as 36 hours after ingestion (Ankeer A 2001).

Within days, liver damage can result, followed by kidney damage.

If liver failure occurs, mortality rates are relatively high (Oz HS et al 2004). Kidney function tests and liver enzyme measurements help assess adverse effects from acetaminophen (Wu E 1994; Brestel E 1994).

Treatment When a person with suspected acetaminophen poisoning is admitted to a hospital, the standard treatment is to administer a prescription drug called Mucosil as rapidly as possible.

This drug inhibits the buildup of toxic by-products in the liver, thus limiting free radical damage and antioxidant depletion. The main ingredient in Mucosil is the nutrient N-acetylcysteine (NAC). In cases of acetaminophen poisoning, NAC should be administered within eight hours of ingestion of the acetaminophen.

NAC stimulates synthesis of glutathione, which reduces free radical damage in the liver (Harris RA et al 2002). It also may act on the acetaminophen metabolite that directly depletes glutathione (Bartlett D 2004; Ankeer A 2001). NAC is most effective when administered even before high acetaminophen levels are confirmed (Ankeer A 2001). Prior to NAC administration to improve liver function, a single dose of charcoal may be administered within the first four hours of acute ingestion to decontaminate acetaminophen not already absorbed in the gastrointestinal tract (Bartlett D 2004). Source Lef.org

Spondylolisthesis, the anterior displacement of a vertebral body in relation to the segment below it, is a relatively common condition. There are five general classifications of spondylolisthesis, the most common being type I (isthmic) - stress fracture in the pars or elongation without separation. Evidence suggests that type I spondylolisthesis is related to upright stance, with the condition perhaps representing a fatigue fracture caused by ambulatory activities.

Whether or not spondylolisthesis produces back pain is a hotly debated topic. For those who think that pain is produced by this condition, the specific mechanism for pain production remains elusive. The purpose of this study was to "observe whether a causal relationship exists between and L5/S1 isthmic spondylolisthesis and the symptoms of back pain." Subjects presenting with spondylolisthesis and a grade 1 listing at L5/S1 were divided into three groups for comparison: 57 symptomatic spondylolisthesis subjects; 29 asymptomatic spondylo- listhesis subjects; and 63 asymptomatic non-spondylolisthesis subjects (the control group).

Radiological measurements, including intervertebral disc (IVD) angle and sacral base angle (SBA) were made from film obtained from two private clinics and the Macquarie University Outpatients Clinic. Results showed that average SBA was significantly higher (43.1) in symptomatic and asymptomatic patients than in non-spondylolisthesis patients. Additionally, the lumbosacral disc angle was significantly smaller in the spondylolisthesis groups compared with the non-spondylolisthesis group.

Conclusion: "The high incidence of L4/L5 hyperextension, the variability in disc angles, and the increased sacral base angulation in symptomatic spondylolisthesis patients illustrate biomechanical changes and dysfunction, and offer possible explanations for the origin of symptoms associated with spondylolisthesis."

Bull P, Hayek R, Cameron J, et al. The effects of spondylolisthesis on the lumbar spine: a cross-sectional radiological survey. Chiropractic Journal of Australia, March 2000:30(1), pp5-12. Reprints: Tel: +61 2 6921 3238; Fax: +61 2 6926 2556; e-mail: chance@wagga.net.au

Study; Randomized clinical trials and systematic reviews An Overview of Evidence for the use of Manual therapy for neck pain The evidence reviewed in a new published study by researchers provides support for the contention that the MTs which induce joint mobility—manipulation and mobilization—are effective in the treatment of neck pain, especially chronic neck pain and neck pain due to whiplash injury, in those subjects who have been randomized to receive these therapies. While intergroup changes were not the focus of this review, the evidence reviewed here does not, in general, contradict the current consensus that MTs, particularly manipulation or mobilization have been shown to be superior to each other or to other treatments to which they have been compared. The consensus approach to include MTs in a multimodal therapeutic approach is still valid and sensible. Despite the variability in reported outcomes, a number of current clinical guidelines have positively endorsed MTs in the treatment of neck pain. H. Vernon, B.K. Humpherys EURA Medicophys 2007, 43-91-118

Commentary; The current evidence for chiropractic’s efficacy for spinal conditions is quite good. In fact, a substantial amount of literature suggests it is superior to the traditional, nonsurgical, medical interventions Chiropractic has been demonstrated to be both very safe and, in most studies, more effective than medicine. Arthor Croft D.C.

PermaLink [#] - Posted to the Chiropractic Department - -

Flexion distraction is a commonly used form of chiropractic care, with utilization rates of 58%. However, according to the authors of the current study, no randomized clinical trial has assessed the effectiveness of this treatment. Two hundred and thirty-five subjects who were previously randomized to either chiropractic care (flexion distraction) or physical therapy (exercise program) were followed for one year via mailed questionnaires to assess levels of pain and dysfunction.

Results: Subjects had a decrease in pain and disability after intervention, regardless of which group they were in. However, during the year after care, subjects who received chiropractic care (flexion distraction therapy) had significantly lower pain scores than subjects who received physical therapy (exercise program).

The authors conclude: "Flexion distraction was found to be more effective in reducing pain for 1 year when compared to a form of physical therapy."

Cambron JA, Gudavalli MR, Hedeker D, McGregor M, Jedlicka J, Keenum M, et al. One-year follow-up of a randomized clinical trial comparing flexion distraction with an exercise program for chronic low-back pain. Journal of Alternative and Complementary Medicine, September 2006;12(7):659-68.

Neck-pain task force issues key findings The Bone and Joint Decade 2000-2010 Task Force on Neck Pain has concluded that neck pain is common, typically has no single cause — or single effective treatment — and Chiropractic treatment is as SAFE as any treatment offered by primary-care medical doctors. The results were published online in the peer-reviewed journal Spine, available by subscription. The study was the work of an elite multidisciplinary team of researchers and clinicians led by Task Force President Scott Haldeman, MD, Phd, DC, of Santa Ana, Calif. Among the key findings of the task force were: • No ‘best’ treatment exists. Use a variety or combination of therapies, according to what the patient wants. • Cervical manipulation is a reasonable option for Grades 1 and 2 pain. The task force concluded the risk of vertebrobasilar (VBA) stroke associated with a visit to a chiropractor appears to be no different from the risk of stroke following a visit to an MD’s office. The full report is available through Spine, www.spinejournal.com. Sources: World Federation of Chiropractic, www.wfc.org; The Bone and Joint Decade Task Force on Neck Pain.

Can Correction of a Misaligned Atlas Reduce Blood Pressure? Results of University of Chicago Pilot Study Are Promising

In a pilot study conducted at the University of Chicago, a one-time specialized chiropractic adjustment, delivered to patients suffering from high blood pressure and misaligned C1 vertebrae, resulted in significant reductions in diastolic and systolic BP compared to controls. According to a press release from the University of Chicago Medical Center, Office of Public Affairs, the decrease in BP was equivalent to that seen with concurrent administration of two blood pressure drugs. None of the patients took any antihypertensive medications during the study period.

The study was led by George Bakris, MD, director of the Hypertension Center at the University of Chicago Medical Center. Study participants were referred to Dr. Marshall Dickholtz Sr., a Chicago-area chiropractor and member of the National Upper Cervical Chiropractic Association (NUCCA), for cervical assessment, including paracervical skin temperature determination, postural analysis, pre-alignment craniocervical X-rays, and supine leg-length check. NUCCA practitioners focus on precise manual adjustment of the Atlas.

Half of the 50 patients received a NUCCA adjustment, while the remaining half received a sham procedure, carefully designed to mimic the actual adjustment in order to ensure blinding. This was possible due to the delicate nature of the C1 adjustment. The primary outcome measure, assessed after eight weeks, was change in systolic and diastolic BP compared to baseline readings. Average age of the study participants was 52.7 years; 70 percent were male.

At week eight, differences were noted in systolic and diastolic BP when comparing the adjustment group with the control group (patients receiving the NUCCA adjustment: –17±9 mm Hg systolic, –10±9 mm Hg diastolic; patients receiving sham treatment: –3±11 mm Hg systolic, –2±7 mm Hg diastolic). Additionally, patients administered the NUCCA adjustment showed 0.04 degrees lateral displacement of C1 after eight weeks, compared to 1.0 degrees at baseline. By comparison, patients in the control group had an average of 0.5 degrees displacement after eight weeks, compared to 0.6 degrees at baseline.

The study authors emphasize that “[while] the mechanism as to why this improvement in blood pressure occurs is unknown and cannot be determined by this study … the data presented, however, raise a number of important questions including a) How does misalignment of C1 affect hypertension?; and b) If there is a cause and effect relationship between C1 and hypertension, is malposition of C1 an additional risk factor for the development of hypertension?” A larger clinical trial is being planned to address these questions.

Resources

1. Bakris G, Dickholtz M, Meyer PM, et al. Altas vertebra realignment and achievement of arterial pressure goal in hypertensive patients: a pilot study. Journal of Human Hypertension, March 2, 2007 (advance online publication). 2. “Special Chiropractic Adjustment Lowers Blood Pressure Among Hypertensive Patients With Misaligned C-1 Vertebra.” Press release from the University of Chicago Medical Center, Office of Public Affairs, March 14, 2007. 3. For additional information about the National Upper Cervical Chiropractic Association, visit www.nucca.org.

Randomised comparison of chiropractic and hospital outpatient management for low back pain: results from extended follow up T W Meade, director,a Sandra Dyer, statistician,a Wendy Browne, research nurse,a A O Frank, consultant in rheumatology and rehabilitation b

a Medical Research Council Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, Medical College of St Bartholomew's Hospital, London EC1M 6BQ, b Northwick Park Hospital, Harrow HA1 3UJ

Correspondence to: Professor Meade.

Abstract

Objective: To compare the effectiveness over three years of chiropractic and hospital outpatient management for low back pain. Design: Randomised allocation of patients to chiropractic or hospital outpatient management. Setting: Chiropractic clinics and hospital outpatient departments within reasonable travelling distance of each other in 11 centres. Subjects: 741 men and women aged 18-64 years with low back pain in whom manipulation was not contraindicated. Outcome measures: Change in total Oswestry questionnaire score and in score for pain and patient satisfaction with allocated treatment. Results: According to total Oswestry scores improvement in all patients at three years was about 29% more in those treated by chiropractors than in those treated by the hospitals. The beneficial effect of chiropractic on pain was particularly clear. Those treated by chiropractors had more further treatments for back pain after the completion of trial treatment. Among both those initially referred from chiropractors and from hospitals more rated chiropractic helpful at three years than hospital management. Conclusions: At three years the results confirm the findings of an earlier report that when chiropractic or hospital therapists treat patients with low back pain as they would in day to day practice those treated by chiropractic derive more benefit and long term satisfaction than those treated by hospitals. Source British Medical Journal

Given the voluminous scientific data demonstrating the myriad associations between declining hormone levels and age-related disorders such as Alzheimer’s and heart disease,1-3 there should be no doubt that hormone testing is an essential element of every annual check-up and disease-prevention program.

In the March 2004 issue of the Journal of Urology, researchers from the University of Pittsburgh suggest that testing for a protein called EPCA could detect prostate cancer up to five years in advance of the prostate specific antigen (PSA) test currently used to screen for the disease as well as other prostate conditions. Prostate specific antigen is a blood marker released by the prostate gland that is frequently elevated with prostate cancer, but an elevation in PSA does not always mean that the patient has cancer. The team believes that testing for EPCA could assist in diagnosing patients with elevated PSA levels who are frequently subjected to repeated needle biopsies

Avastin, approved by the U.S. Food and Drug Administration last week for treating advanced colon cancer, works precisely that way: It starves cancers by depriving them of the nutrients they need to grow and spread. A synthetic antibody developed by Genentech, Avastin was the second targeted cancer drug to be approved in two weeks. On Feb. 12, another antibody, Erbitux, won FDA clearance for a later stage of the same disease. (Erbitux, developed by ImClone Systems, is the drug at the heart of the Martha Stewart stock-trading scandal.) Both drugs are for intravenous injection and are being shipped to hospital pharmacies. Hospitals said the drugs are either already in stock or will be available this week. "These drugs add to the growing list of new, specifically targeted treatments [that are] effective, less toxic and useful in a host of different cancers: breast, lung, colon and others

Researchers from Duke University have developed a new theory of why atherosclerosis is primarily a disease associated with age. Cardiologists Pascal Goldschmidt, MD and Eric Peterson, MD, believe that the body’s declining ability to repair itself, specifically with stem cells produced in the bone marrow, may be the reason why cardiovascular events increase with age and may help explain the individual variations in susceptibility to the condition.

According to Lois Swirsky Gold who directs the Carcinogenic Potency Project at UC Berkeley and Lawrence Berkeley National Laboratory, reports that a Dangerous Chinese herb product known to cause kidney failure and cancer in people and banned for importation two years ago by the U.S. Food & Drug Administration is being sold on the WEB "... aristolochic acid is among the most potent two percent of the carcinogens in our Carcinogenic Potency Database." Many names are used including fang ji (Aristolochia fangchi) and wild ginger (Asarum canadense). The herb products, which include those marketed as "Cramp Relief," "Cold Away," "Mother Earth's Cough Syrup," "Old Indian Herbal Syrup" and "PMS-Ease,"

According to the Peer Reviewed Studies By the Children's Chiropractic Research Foundation Conclusion: The results indicate that there is a strong correlation between the chiropractic adjustment and the resolution of otitis media for the children in this study. Note: 311 of the 332 had a history of prior antibiotic use. 53.7% of the children had their first bout of otitis media between the ages of 6 months and 1 year and a total of 69.9% of the subjects in the study had their first bout of OM under a year of age.

A “short communication” published in Cancer Epidemiology, Biomarkers & Prevention’s September 2003 issue described how researchers at the University of Colorado Health Sciences Center in Denver discovered After sixty days the tumors were assessed for cell proliferation, apoptosis (programmed cell self-destruction) and angiogenesis (the formation of new blood vessels by the tumors which facilitates their growth). They found that while cell proliferation and angiogenesis were reduced, apoptosis increased.

According to a study published in the Journal Circulation 2003 Data suggests that regular but not intermittent use of NSAIDs inhibits the clinical benefits of aspirin. There is clear evidence from numerous randomized trials and their meta-analyses that aspirin reduces risks of first myocardial infarction (MI). Recent data also suggest that other nonsteroidal anti-inflammatory drugs (NSAIDs) may interfere with this benefit of aspirin.

Fasting every other day is a sure-fire way to good health according to new research in rats. Experiments done at the National Institute on Aging show that skipping meals causes significant and lasting reductions in blood-sugar, blood-pressure and heart rate. The program worked even if it was started in adulthood. And that's not all. Resistance to stress, weight-loss and increased life span (by one-third) were part of the reward of skimpy eating

Researchers in Australia and the U.S. report that giving mice supplemental vitamin E acetate, ginkgo biloba, pycnogenol and ascorbyl palmitate (fat-soluble vitamin C) at doses a human would take, reduces by ten times the number of "inclusion bodies" in brain cells

A study found in the Journal Circulation (peer reviewed scientific journal) found the protective effect of EPA/DHA & olive oil in preventing narrowing of vascular channels after corrective surgery in heart patients with this condition. CONCLUSIONS. This trial documented the protective effect of fish oil supplements on the recurrence of coronary stenosis (narrowing) 6 months after PTCA. The study results suggest that a dietary intervention could be useful in preventing restenosis

While the diet lowered LDL cholesterol by 8 percent, it had no effect on endothelial function in this study. However, participants who received the antioxidant vitamins experienced a restoration of endothelial function to levels found in healthy children

ARLINGTON, VA - Two new studies May 2003 showing that heavy backpacks can lead to both back pain and poor posture in schoolchildren underscore the need for parents to educate their children on the proper use of backpacks, according to the American Chiropractic Association (ACA).

New Research Shows Manipulation Superior to Acupuncture, & Drugs A randomized, controlled clinical trial just published in Spine( a peer reviewed scientific journal) reveals that chiropractic "manipulation" is superior to both drugs and acupuncture in the treatment of chronic spinal pain (people with pain lasting more than 13 weeks).

Mechanism of Intervertebral Disc Degeneration Caused by Nicotine is explored by Japanise researchers From the Department of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan.

Substantial Evidence Shows Efficacy of Chiropractic for safely improving range of motion in patients with Cervicogenic Headaches

What's under your kitchen sink, in your garage, in your bathroom, and on the shelves in your laundry room? Do these household products pose a potential health risk to you and your family?

Find out what's in these products and what are the potential health effects, and other safety and handling information from the National Library of Medicine. Excellent source of information!

Scar tissue (fibrocytes) will infiltrate and replace the original tissue in and around the injury site. Fibrocytes are weaker, less elastic and more pain-sensitive than original soft tissue. When challenged by the movement of the body, fibrocytes will not lengthen and give way; instead...

A food allergy is an immune system response to a food that the body mistakenly believes is harmful. Once the immune system decides that a particular food is harmful, it creates specific antibodies to it. The following eight foods account for 90 percent of all food-allergic reactions: Milk, Egg, Peanut, Tree nut (walnut, cashew, etc.) Fish, Shellfish, Soy, Wheat.

Cool site with ideas for games and school science projects from Nobel prize winning research. Choose a main topic then educational to view games and projects.

Exercising the Rotator Cuff - Minus the Deltoid The rotator cuff acts in concert with the deltoid to elevate the shoulder. An important function of the cuff muscles is to keep the head of the humerus centered within the glenoid cavity (concavity compression), and at the same time, to impose an inferiorly directed force vector to the humeral head

Children with mild scoliosis treated with chiropractic adjustments have shown a reduction in their spinal curvature, according to the findings of a three-year, $143,000 study funded by the Foundation for Chiropractic Education and Research

The short- and long-term consequences of a radiation disaster are significantly greater in children. First, children have a disproportionately higher minute ventilation, leading to greater internal exposure to radioactive gases. Potassium iodide is of proven value for thyroid protection but must be given before or soon after exposure to radioiodines, requiring its placement in homes, schools, and child care centers. This easy to obtain supplement is a must have item to protect your family.

In some people, especially children, hemolytic uremic syndrome (HUS) can result from infection by a strain of bacteria, E. coli O157:H7, and can lead to kidney failure and death. HUS is is the leading cause of acute renal failure in previously healthy children. The child may become infected after consuming a contaminated food, especially undercooked ground beef, unpasteurized apple cider or apple juice, or raw sprouts

Charges by the Federal Trade Commision vs. Seasilver of fraud. Americaloe Inc. and Seasilver USA Inc., promoted the liquid supplement as a safe treatment or cure for 650 diseases, including AIDS, Lyme disease, various cancers and diabetes in nine out of 10 patients

Fevers can be scary to a parent, general information to help you understand what's going on.

What is the latest news in stem cell research? the NIH has interesting current information on the genetic investigations on a Variety of conditions including Asthma. Asthma is on the rise in the United States and causes at least 5,000 deaths a year. Although the condition remains poorly understood at the fundamental level. Dr. Rothenberg and his colleagues used “gene chip” technology to probe the underpinnings of asthma. What Can Chiropractic do to help the body in a natural and safe way to help? Read Why we need Chiropractic on this page.

The Genetics Home Reference is the National Library of Medicine's web site for consumer information about genetic conditions. Gene therapy is currently available only in a research setting. Hundreds of clinical trials are under way to test gene therapy for genetic conditions, cancer, and HIV/AIDS. Search for clinical trials online. ClinicalTrials.gov, The National Institutes of Health, provides access to information on clinical trials at http://clinicaltrials.gov. Search for specific trials or browse by condition. A list of gene therapy trials that are accepting patients is available at http://clinicaltrials.gov/search/term=gene+therapy.

Why is it important to receive regular chiropractic adjustments? Your spine has the ability to withstand compressive loading sometimes referred to as axial loading.

When soft tissues are stressed they produce a group of chemicals called inflammatories. These include histamine, bradykinin, and prostaglandin. These chemicals are designed to provoke specicific responses, which are supposed to be part of the healing process.

All Cancer results from the accumulation of mutations in genes that regulate cellular proliferation. A common pathway towards cancer occurs when diatary mutagenic agents cause adducts to be formed on genes. Adducts (gene alterations) are formed when a carcinogen binds to DNA

Colorectal cancer is the second leading cause of death due to malignancy in the United States. It is the first cause of death due to malignancy in men and the second in women. A new study has again demonstrated the anti cancer effects of regular use of Folic Acid.

A herbal alternative marketed as GlucoCare or Glucosim in the USA has been found to be safe and effective.

"It is possible to evaluate and even improve your child's natural hand eye coordination"

Screening available for the #1 one cause of death for men and the #2 cause of death for women due to malignancy in the USA

If periods bring you nothing but pain, a few key nutritional changes might offer the relief you need.

A good link to CDC information on Smallpox, Sarin nerve gas, Mustard Gas, Ricin, VX, Anthrax, Botulism, and Radiological Emergencys.

U.S. department of Health and Human services has concluded that the dietary supplement called S-adenosyl-methionine (SAMe) is effective as prescription drugs used to treat depression and osteoarthritis. Studies show improved liver function, and it reduces pain and improves mobility in osteoarthritis, and may prevent brain aging. Major difference SAMe is natural without side effects..